U 47700 Popular Research Chemicals, Analgesic Opioid Research Chemicals Powder

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Agent
Country
USA
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U-47700 is an opioid analgesic drug developed by a team at Upjohn in the 1970s that acts as a selective agonist of the -opioid receptor with a Kd value of 5.3 nM compared to 910 nM for the -opioid receptor and has around 7.5 x the potency of morphine in animal models. U-47700 is a structural isomer of the earlier opioid AH-7921 and the result of a great deal of work elucidating the quantitative structureactivity relationship of the scaffold. Upjohn looked for the key moieties which gave the greatest activity and posted over a dozen patents on related compounds, each optimizing one moiety until they discovered that U-47700 was the most active. U-47700 became the lead compound of selective kappa-opioid receptor ligands such as U-50488, U-51754 (containing a single methylene spacer difference) and U-69,593, which share very similar structures. Although not used medically, the selective kappa ligands are used in research.
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Company
Business Type
Agent
Established
2000
Employess
Below 5 People
Annual Revenue
US$1 Million - US$2.5 Million
Main Markets
North America, Eastern Europe, East Asia, Africa, South America, Southern Europe, South Asia, Oceania, Central America, Western Europe
Export Ratio
41% - 50%
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USA

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